EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent

EED orchestration of heart maturation through interaction with HDACs is H3K27me3-independent

In proliferating cells, where most Polycomb repressive complex 2 (PRC2) studies have been performed, gene repression is associated with PRC2 trimethylation of H3K27 (H3K27me3). However, it is uncertain whether PRC2 writing of H3K27me3 is mechanistically required for gene silencing. Here, we studied...

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Bibliographic Details
Main Authors: Shanshan Ai, Yong Peng, Chen Li, Fei Gu, Xianhong Yu, Yanzhu Yue, Qing Ma, Jinghai Chen, Zhiqiang Lin, Pingzhu Zhou, Huafeng Xie, Terence W Prendiville, Wen Zheng, Yuli Liu, Stuart H Orkin, Da-Zhi Wang, Jia Yu, William T Pu, Aibin He
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-04-01
Series:eLife
Subjects:
cardiology
gene regulation
chromatin
heart development
Online Access:https://elifesciences.org/articles/24570

Internet

https://elifesciences.org/articles/24570

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