STING regulates metabolic reprogramming in macrophages via HIF-1α during Brucella infection.

STING regulates metabolic reprogramming in macrophages via HIF-1α during Brucella infection.

Macrophages metabolic reprogramming in response to microbial insults is a major determinant of pathogen growth or containment. Here, we reveal a distinct mechanism by which stimulator of interferon genes (STING), a cytosolic sensor that regulates innate immune responses, contributes to an inflammato...

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Bibliographic Details
Main Authors: Marco Tulio R Gomes, Erika S Guimarães, Fabio V Marinho, Isabella Macedo, Eric R G R Aguiar, Glen N Barber, Pedro M M Moraes-Vieira, José Carlos Alves-Filho, Sergio C Oliveira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009597

Internet

https://doi.org/10.1371/journal.ppat.1009597

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