Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase[S]

Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase[S]

Hydroxy-3-methyl-glutaryl-CoA reductase (HMGR) is the rate-controlling enzyme of cholesterol synthesis, and owing to its biological and pharmacological relevance, researchers have investigated several compounds capable of modulating its activity with the hope of developing new hypocholesterolemic dr...

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Bibliographic Details
Main Authors: Massimiliano Cuccioloni, Matteo Mozzicafreddo, Michele Spina, Chi Nhan Tran, Maurizio Falconi, Anna Maria Eleuteri, Mauro Angeletti
Format: Article
Language:English
Published: Elsevier 2011-05-01
Series:Journal of Lipid Research
Subjects:
cholesterol
reduced nicotinamide adenine dinucleotide phosphate
epigallocatechin-3-gallate
inhibition
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520408764

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http://www.sciencedirect.com/science/article/pii/S0022227520408764

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