MP-12 virus containing the Clone 13 deletion in the NSs gene prevents lethal disease when administered after Rift Valley fever virus infection in hamsters

MP-12 virus containing the Clone 13 deletion in the NSs gene prevents lethal disease when administered after Rift Valley fever virus infection in hamsters

Rift Valley fever virus (RVFV; Bunyaviridae, Phlebovirus) causes a range of illnesses that include retinitis, fulminant hepatitis, neurologic disease, and hemorrhagic fever. In hospitalized individuals, case fatality rates can be as high as 10-20%. There are no vaccines or antivirals approved for...

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Bibliographic Details
Main Authors: Brian B Gowen, Jonna B Westover, Eric J Sefing, Kevin W Bailey, Shoko eNishiyama, Luci eWandersee, Dionna eScharton, Kie-Hoon eJung, Tetsuro eIkegami
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Microbiology
Subjects:
Phlebovirus
Rift Valley fever virus
Vaccine
viral hemorrhagic fever
Post-exposure
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00651/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00651/full

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