The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels

The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels control spontaneous electrical activity in heart and brain. Binding of cAMP to the cyclic nucleotide-binding domain (CNBD) facilitates channel opening by relieving a tonic inhibition exerted by the CNBD. Despite high resolution struc...

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Bibliographic Details
Main Authors: Alessandro Porro, Andrea Saponaro, Federica Gasparri, Daniel Bauer, Christine Gross, Matteo Pisoni, Gerardo Abbandonato, Kay Hamacher, Bina Santoro, Gerhard Thiel, Anna Moroni
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
HCN
cAMP
HCN domain
gating
N terminus
Online Access:https://elifesciences.org/articles/49672

Internet

https://elifesciences.org/articles/49672

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