A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

Abstract Background Mutations in KRAS are frequent in human cancer, yet effective targeted therapeutics for these cancers are still lacking. Attempts to drug the MEK kinases downstream of KRAS have had limited success in clinical trials. Understanding the specific genomic vulnerabilities of KRAS-dri...

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Bibliographic Details
Main Authors: Tonći Šuštić, Sake van Wageningen, Evert Bosdriesz, Robert J. D. Reid, John Dittmar, Cor Lieftink, Roderick L. Beijersbergen, Lodewyk F. A. Wessels, Rodney Rothstein, René Bernards
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Genome Medicine
Subjects:
Ire1
ERN1
MEK inhibitor
Colon cancer
JNK
JUN
Online Access:http://link.springer.com/article/10.1186/s13073-018-0600-z

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http://link.springer.com/article/10.1186/s13073-018-0600-z

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