The Role of Endothelial Ca2+ Signaling in Neurovascular Coupling: A View from the Lumen

The Role of Endothelial Ca2+ Signaling in Neurovascular Coupling: A View from the Lumen

Background: Neurovascular coupling (NVC) is the mechanism whereby an increase in neuronal activity (NA) leads to local elevation in cerebral blood flow (CBF) to match the metabolic requirements of firing neurons. Following synaptic activity, an increase in neuronal and/or astrocyte Ca2+ concentratio...

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Bibliographic Details
Main Authors: Germano Guerra, Angela Lucariello, Angelica Perna, Laura Botta, Antonio De Luca, Francesco Moccia
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:International Journal of Molecular Sciences
Subjects:
neurovascular coupling
neuronal activity
brain endothelial cells
Ca2+ signaling
glutamate
acetylcholine
ATP
nitric oxide
endothelial-dependent hyperpolarization
TRP channels
Online Access:http://www.mdpi.com/1422-0067/19/4/938

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http://www.mdpi.com/1422-0067/19/4/938

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