Cancer immunotherapy by targeting IDO1/TDO and their downstream effectors

Cancer immunotherapy by targeting IDO1/TDO and their downstream effectors

The tryptophan to kynurenine metabolic pathway is now firmly established as a key regulator of innate and adaptive immunity. A plethora of preclinical models suggests that this immune tolerance pathway - driven by the key and rate-limiting enzymes indoleamine-2,3-dioxygenase and tryptophan-2,3-dioxy...

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Bibliographic Details
Main Authors: Michael ePlatten, Nikolaus evon Knebel Doeberitz, Iris eOezen, Wolfgang eWick, Katharina eOchs
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Immunology
Subjects:
IDO
AhR
tumor immunity
tryptophan metabolism
TDO
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00673/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00673/full

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