Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice

Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice

Background/Aims Intestinal fibrosis is a major complication of Crohn’s disease (CD). The profibrotic protein transforming growth factor-β (TGF-β) has been considered to be critical for the induction of the fibrotic program. TGF-β has the ability to induce not only the expression of extracellular mat...

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Bibliographic Details
Main Authors: Jin Imai, Takashi Yahata, Hitoshi Ichikawa, Abd Aziz Ibrahim, Masaki Yazawa, Hideaki Sumiyoshi, Yutaka Inagaki, Masashi Matsushima, Takayoshi Suzuki, Tetsuya Mine, Kiyoshi Ando, Toshio Miyata, Katsuto Hozumi
Format: Article
Language:English
Published: Korean Association for the Study of Intestinal Diseases 2020-04-01
Series:Intestinal Research
Subjects:
plasminogen activator inhibitor-1
matrix metalloproteinase 9
intestinal fibrosis
crohn disease
2,4,6-trinitrobenzene sulfonic acid
Online Access:http://www.irjournal.org/upload/pdf/ir-2019-00037.pdf

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http://www.irjournal.org/upload/pdf/ir-2019-00037.pdf

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