O-6-methylguanine-deoxyribonucleic acid methyltransferase methylation enhances response to temozolomide treatment in esophageal cancer

O-6-methylguanine-deoxyribonucleic acid methyltransferase methylation enhances response to temozolomide treatment in esophageal cancer

Background: World-wide, esophageal cancer is a growing epidemic and patients frequently present with advanced disease that is surgically inoperable. Hence, chemotherapy is the predominate treatment. Cytotoxic platinum compounds are mostly used, but their efficacy is only moderate. Newer alkylating a...

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Bibliographic Details
Main Authors: Rifat Hasina, Mosmi Surati, Ichiro Kawada, Qudsia Arif, George B Carey, Rajani Kanteti, Aliya N Husain, Mark K Ferguson, Everett E Vokes, Victoria M Villaflor, Ravi Salgia
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2013-01-01
Series:Journal of Carcinogenesis
Subjects:
Alkylating agents
deoxyribonucleic acid repair genes
in vivo pre-clinical
esophageal cancer
O-6-methylguanine-deoxyribonucleic acid methyltransferase hypermethylation
response to treatment
temozolomide
Online Access:http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2013;volume=12;issue=1;spage=20;epage=20;aulast=Hasina

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http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2013;volume=12;issue=1;spage=20;epage=20;aulast=Hasina

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