TDP-43 prevents endogenous RNAs from triggering a lethal RIG-I-dependent interferon response

TDP-43 prevents endogenous RNAs from triggering a lethal RIG-I-dependent interferon response

Summary: RIG-I-like receptors (RLRs) are involved in the discrimination of self versus non-self via the recognition of double-stranded RNA (dsRNA). Emerging evidence suggests that immunostimulatory dsRNAs are ubiquitously expressed but are disrupted or sequestered by cellular RNA binding proteins (R...

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Bibliographic Details
Main Authors: William Dunker, Xiang Ye, Yang Zhao, Lanxi Liu, Antiana Richardson, John Karijolich
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
TDP-43
double-stranded RNA
RIG-I-like receptors
RNA binding protein
necroptosis
gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002904

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http://www.sciencedirect.com/science/article/pii/S2211124721002904

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