MHC Class I Stability is Modulated by Cell Surface Sialylation in Human Dendritic Cells

MHC Class I Stability is Modulated by Cell Surface Sialylation in Human Dendritic Cells

Maturation of human Dendritic Cells (DCs) is characterized by increased expression of antigen presentation molecules, and overall decreased levels of sialic acid at cell surface. Here, we aimed to identify sialylated proteins at DC surface and comprehend their role and modulation. Mass spectrometry...

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Bibliographic Details
Main Authors: Zélia Silva, Tiago Ferro, Danielle Almeida, Helena Soares, José Alexandre Ferreira, Fanny M. Deschepper, Paul J. Hensbergen, Martina Pirro, Sandra J. van Vliet, Sebastian Springer, Paula A. Videira
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Pharmaceutics
Subjects:
dendritic-cells
antigen-presentation
mhc-i
immunogenicity
t-cell response
cancer-vaccines
Online Access:https://www.mdpi.com/1999-4923/12/3/249

Internet

https://www.mdpi.com/1999-4923/12/3/249

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