Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme

Ribonulease P is a conserved ribozyme present in all kingdoms of life that is involved in the 5′ maturation step of tRNAs. Here the authors determine the structure of an archaeal RNase P holoenzyme that reveals how archaeal RNase P recognizes its tRNA substrate and suggest a conserved catalytic mech...

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Bibliographic Details
Main Authors: Futang Wan, Qianmin Wang, Jing Tan, Ming Tan, Juan Chen, Shaohua Shi, Pengfei Lan, Jian Wu, Ming Lei
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10496-3