Inhibition of Ectopic Arginine Vasopressin Production by Phenytoin in the Small Cell Lung Cancer Cell Line Lu-165

Inhibition of Ectopic Arginine Vasopressin Production by Phenytoin in the Small Cell Lung Cancer Cell Line Lu-165

Phenytoin, a voltage-gated sodium channel (NaV channel) antagonist, reportedly inhibits arginine vasopressin (AVP) release from an isolated rat neurohypophysis. So far, it is uncertain whether phenytoin has a direct action on ectopic AVP-producing neuroendocrine tumors. We studied the effect of phen...

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Bibliographic Details
Main Authors: Masaru Shoji, Takahiro Ohta, Mitsuo Mita, Shigeru Hishinuma, Reiko Ishii-Nozawa, Kazuhisa Takahashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Endocrinology
Subjects:
phenytoin
vasopressin
copeptin
voltage-gated sodium channel
small cell lung cancer
syndrome of inappropriate antidiuretic hormone secretion
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00094/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2017.00094/full

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