Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors

Cytotoxic substituted indolizines as new colchicine site tubulin polymerisation inhibitors

A potential microtubule destabilising series of new indolizine derivatives was synthesised and tested for their anticancer activity against a panel of 60 human cancer cell lines. Compounds 11a, 11b, 15a, and 15j showed a broad spectrum of growth inhibitory activity against cancer cell lines represen...

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Bibliographic Details
Main Authors: Monica-Cornelia Sardaru, Anda Mihaela Craciun, Cristina-Maria Al Matarneh, Isabela Andreea Sandu, Roxana Maria Amarandi, Lacramioara Popovici, Catalina Ionica Ciobanu, Dragos Peptanariu, Mariana Pinteala, Ionel I. Mangalagiu, Ramona Danac
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
indolizine
anticancer
tubulin polymerisation inhibitors
phenstatin
pyridyl
Online Access:http://dx.doi.org/10.1080/14756366.2020.1801671

Internet

http://dx.doi.org/10.1080/14756366.2020.1801671

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