The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health

The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health

SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide. The complex is responsible for uptake of essential amino acids in crucial body districts such as placenta and blood br...

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Bibliographic Details
Main Authors: Mariafrancesca Scalise, Michele Galluccio, Lara Console, Lorena Pochini, Cesare Indiveri
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Chemistry
Subjects:
LAT1
SLC7 family
histidine
drug design
pro-drugs
proteoliposomes
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2018.00243/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2018.00243/full

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