Voltage- and temperature-dependent allosteric modulation of alpha7 nicotinic receptors by PNU120596

Voltage- and temperature-dependent allosteric modulation of alpha7 nicotinic receptors by PNU120596

Alpha7 nicotinic receptors (a7nAChR) are widely distributed throughout the central nervous system (CNS) and are found at particularly high levels in the hippocampus and cortex. Several lines of evidence indicate that pharmacological enhancement of a7nAChRs function could be a potential therapeutic r...

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Bibliographic Details
Main Authors: Fabrio eSitzia, Jon T Brown, Andrew eRandall, John eDunlop
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-12-01
Series:Frontiers in Pharmacology
Subjects:
Electrophysiology
nicotinic receptors
patch clamp
allosteric modulator
channel
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00081/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00081/full

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