New Insights into the Mechanism of Action of Soluble Klotho

The klotho gene encodes a type I single-pass transmembrane protein that contains a large extracellular domain, a membrane spanning segment, and a short intracellular domain. Klotho protein exists in several forms including the full-length membrane form (mKl) and a soluble circulating form [soluble k...

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Bibliographic Details
Main Authors: George D. Dalton, Jian Xie, Sung-Wan An, Chou-Long Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Endocrinology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00323/full