Effect of Dihydroartemisinin-Piperaquine on the Pharmacokinetics of Praziquantel for Treatment of <i>Schistosoma mansoni</i> Infection

Effect of Dihydroartemisinin-Piperaquine on the Pharmacokinetics of Praziquantel for Treatment of <i>Schistosoma mansoni</i> Infection

Praziquantel (PZQ) and dihydroartemisinin-piperaquine (DHP) combination recently showed superior effectiveness than PZQ alone to treat intestinal schistosomiasis. In this follow-up study, we investigated the effect of DHP co-administration on the pharmacokinetics of PZQ and its enantiomers among 64...

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Bibliographic Details
Main Authors: Omary Mashiku Minzi, Rajabu Hussein Mnkugwe, Eliford Ngaimisi, Safari Kinung’hi, Anna Hansson, Anton Pohanka, Appolinary Kamuhabwa, Eleni Aklillu
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceuticals
Subjects:
dihydroartemisinin-piperaquine
praziquantel
praziquantel enantiomers pharmacokinetics interaction
<i>Schistosoma mansoni</i>
Online Access:https://www.mdpi.com/1424-8247/14/5/400

Internet

https://www.mdpi.com/1424-8247/14/5/400

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