A systematically combined genotype and functional combination analysis of CYP2E1, CYP2D6, CYP2C9, CYP2C19 in different geographic areas of mainland China--a basis for personalized therapy.

A systematically combined genotype and functional combination analysis of CYP2E1, CYP2D6, CYP2C9, CYP2C19 in different geographic areas of mainland China--a basis for personalized therapy.

The cytochrome P450 is the major enzyme involved in drug metabolism. Single CYP genotypes and metabolic phenotypes have been widely studied, but no combination analysis has been conducted in the context of specific populations and geographical areas. This study is the first to systematically analyze...

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Bibliographic Details
Main Authors: Zhenqiang Wu, Xiaoqing Zhang, Lu Shen, Yuyu Xiong, Xi Wu, Ran Huo, Zhiyun Wei, Lei Cai, Guoyang Qi, Qingqing Xu, Daxiang Cui, Donghong Cui, Gengchun Zhao, Lin He, Shengying Qin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3788764?pdf=render

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http://europepmc.org/articles/PMC3788764?pdf=render

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