Biventricular Pacing Cardiac Contractility Modulation Improves Cardiac Contractile Function via Upregulating SERCA2 and miR-133 in a Rabbit Model of Congestive Heart Failure

Biventricular Pacing Cardiac Contractility Modulation Improves Cardiac Contractile Function via Upregulating SERCA2 and miR-133 in a Rabbit Model of Congestive Heart Failure

Objective: To compare the effects of biventricular electrical pacing and conventional single-ventricular pacing for cardiac contractility modulation (CCM) on cardiac contractile function and to delineate the underlying molecular mechanisms. Methods: Forty rabbits were divided into four groups before...

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Bibliographic Details
Main Authors: Bin Ning, Xiaoyong Qi, Yingxiao Li, Huiliang Liu, Feifei Zhang, Chen Qin
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
SERCA2a
miR-133
Phospholamban
NCX1
Cardiac contractility modulation (CCM)
Cardiac resynchronization therapy (CRT)
Cardiac contractile function
Absolute refractory period
Electric pacing
Congestive heart failure
Online Access:http://www.karger.com/Article/FullText/358705

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http://www.karger.com/Article/FullText/358705

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