Clogging the Ubiquitin-Proteasome Machinery with Marine Natural Products: Last Decade Update

Clogging the Ubiquitin-Proteasome Machinery with Marine Natural Products: Last Decade Update

The ubiquitin-proteasome pathway (UPP) is the central protein degradation system in eukaryotic cells, playing a key role in homeostasis maintenance, through proteolysis of regulatory and misfolded (potentially harmful) proteins. As cancer cells produce proteins inducing cell proliferation and inhibi...

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Bibliographic Details
Main Authors: Gerardo Della Sala, Francesca Agriesti, Carmela Mazzoccoli, Tiziana Tataranni, Valeria Costantino, Claudia Piccoli
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Marine Drugs
Subjects:
natural products
ubiquitin
proteasome
marine
salinosporamide
cancer
high-throughput screening
secondary metabolites
lead compounds
Online Access:https://www.mdpi.com/1660-3397/16/12/467

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https://www.mdpi.com/1660-3397/16/12/467

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