Intravitreal injection of aflibercept, an anti-VEGF antagonist, down-regulates plasma von Willebrand factor in patients with age-related macular degeneration

Abstract We investigated the association between von Willebrand factor (VWF) and exudative age-related macular degeneration (AMD) in 114 Japanese patients. Intravitreal injection of vascular endothelial growth factor (VEGF) inhibitor is the most effective therapy for AMD. Therefore, we analyzed chan...

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Bibliographic Details
Main Authors: Mariko Yamashita, Masanori Matsumoto, Masaki Hayakawa, Kazuya Sakai, Yoshihiro Fujimura, Nahoko Ogata
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-19473-0