Impact of mutations in highly conserved amino acids of the HIV-1 Gag-p24 and Env-gp120 proteins on viral replication in different genetic backgrounds.

Impact of mutations in highly conserved amino acids of the HIV-1 Gag-p24 and Env-gp120 proteins on viral replication in different genetic backgrounds.

It has been hypothesized that a single mutation at a highly conserved amino acid site (HCS) can be severely deleterious to HIV in most if not all isolate-specific genetic backgrounds. Consequently, potentially universal HIV-1 vaccines exclusively targeting highly conserved regions of the viral prote...

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Bibliographic Details
Main Authors: Yi Liu, Ushnal Rao, Jan McClure, Philip Konopa, Siriphan Manocheewa, Moon Kim, Lennie Chen, Ryan M Troyer, Denis M Tebit, Sarah Holte, Eric J Arts, James I Mullins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3979772?pdf=render

Internet

http://europepmc.org/articles/PMC3979772?pdf=render

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