The Mechanism behind Bacterial Lipoprotein Release: Phenol-Soluble Modulins Mediate Toll-Like Receptor 2 Activation via Extracellular Vesicle Release from Staphylococcus aureus

The Mechanism behind Bacterial Lipoprotein Release: Phenol-Soluble Modulins Mediate Toll-Like Receptor 2 Activation via Extracellular Vesicle Release from Staphylococcus aureus

Our study highlights the roles of surfactant-like molecules in bacterial inflammation with important implications for the prevention and therapy of inflammatory disorders. It describes a potential pathway for the transfer of hydrophobic bacterial lipoproteins, the major TLR2 agonists, from the cytop...

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Bibliographic Details
Main Authors: Katja Schlatterer, Christian Beck, Dennis Hanzelmann, Marco Lebtig, Birgit Fehrenbacher, Martin Schaller, Patrick Ebner, Mulugeta Nega, Michael Otto, Dorothee Kretschmer, Andreas Peschel
Format: Article
Language:English
Published: American Society for Microbiology 2018-11-01
Series:mBio
Subjects:
Staphylococcus aureus
leukocytes
lipoproteins
pore-forming toxins
Toll-like receptors
vesicles
Online Access:https://doi.org/10.1128/mBio.01851-18

Internet

https://doi.org/10.1128/mBio.01851-18

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