Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity.
SKN-1, the Caenorhabditis elegans Nrf1/2/3 ortholog, promotes both oxidative stress resistance and longevity. SKN-1 responds to oxidative stress by upregulating genes that detoxify and defend against free radicals and other reactive molecules, a SKN-1/Nrf function that is both well-known and conserv...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-06-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC3111486?pdf=render |