Decreased Production of TNF-α and IL-6 Inflammatory Cytokines in Non-Pregnant Idiopathic RPL Women Immunomodulatory Effect of Sildenafil Citrate on the Cellular Response of Idiopathic RPL Women

Decreased Production of TNF-α and IL-6 Inflammatory Cytokines in Non-Pregnant Idiopathic RPL Women Immunomodulatory Effect of Sildenafil Citrate on the Cellular Response of Idiopathic RPL Women

Sildenafil citrate (SC), a PDE5 inhibitor, a drug for erectile dysfunction (ED) and pulmonary hypertension (PAH), was found to exert a positive effect on pregnancy outcomes when administered intravaginally before conception. In our previous studies, sildenafil increased endometrial thickness and sig...

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Bibliographic Details
Main Authors: Monika Kniotek, Michał Zych, Aleksander Roszczyk, Monika Szafarowska, Małgorzata Maria Jerzak
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Journal of Clinical Medicine
Subjects:
cytokines
recurrent pregnancy loss
sildenafil citrate
Treg cells
Th1/Th2 cells
Th17 cells
Online Access:https://www.mdpi.com/2077-0383/10/14/3115

Internet

https://www.mdpi.com/2077-0383/10/14/3115

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