Lentiviral-mediated overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus ameliorates LPS - induced cognitive impairment in mice

Lentiviral-mediated overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus ameliorates LPS - induced cognitive impairment in mice

The 18 kDa translocator protein (TSPO) is involved in the immune/inflammatory response. However, the exact role that TSPO plays in neuroinflammation-induced cognitive impairment is still elusive. The purpose of our present study was to investigate the effects of lentiviral-mediated hippocampal overe...

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Bibliographic Details
Main Authors: Wei Wang, Liming Zhang, Xiaoying Zhang, Rui Xue, Lei Li, Weixing Zhao, Qiang Fu, Weidong Mi, Yun-Feng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Pharmacology
Subjects:
Hippocampus
Neurogenesis
Neuroinflammation
Allopregnanolone
TSPO
Cognitive impairment
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00384/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00384/full

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