N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells

N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells

Abstract Background KIT tyrosine kinase is expressed in mast cells, interstitial cells of Cajal, and hematopoietic cells. Permanently active KIT mutations lead these host cells to tumorigenesis, and to such diseases as mast cell leukemia (MCL), gastrointestinal stromal tumor (GIST), and acute myeloi...

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Bibliographic Details
Main Authors: Yuuki Obata, Yasushi Hara, Isamu Shiina, Takatsugu Murata, Yasutaka Tasaki, Kyohei Suzuki, Keiichi Ito, Shou Tsugawa, Kouhei Yamawaki, Tsuyoshi Takahashi, Koji Okamoto, Toshirou Nishida, Ryo Abe
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Cell Communication and Signaling
Subjects:
Leukemia
KIT tyrosine kinase
Golgi
Lipid rafts
AKT
STAT5
Online Access:http://link.springer.com/article/10.1186/s12964-019-0426-3

Internet

http://link.springer.com/article/10.1186/s12964-019-0426-3

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