The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway.
Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator beta-catenin. Recent studies have demonstrated that axin, which coordinates beta-catenin degradation, is itself degraded. Although the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2003-10-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC212691?pdf=render |