Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.

Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.

Catechol-O-methyltransferase (COMT) is an enzyme that plays a key role in the modulation of catechol-dependent functions such as cognition, cardiovascular function, and pain processing. Three common haplotypes of the human COMT gene, divergent in two synonymous and one nonsynonymous (val(158)met) po...

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Bibliographic Details
Main Authors: Andrea G Nackley, Svetlana A Shabalina, Jason E Lambert, Mathew S Conrad, Dustin G Gibson, Alexey N Spiridonov, Sarah K Satterfield, Luda Diatchenko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2664927?pdf=render

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http://europepmc.org/articles/PMC2664927?pdf=render

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