A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria

A randomized, double-blind, phase 2b study to investigate the efficacy, safety, tolerability and pharmacokinetics of a single-dose regimen of ferroquine with artefenomel in adults and children with uncomplicated Plasmodium falciparum malaria

Abstract Background For uncomplicated Plasmodium falciparum malaria, highly efficacious single-dose treatments are expected to increase compliance and improve treatment outcomes, and thereby may slow the development of resistance. The efficacy and safety of a single-dose combination of artefenomel (...

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Bibliographic Details
Main Authors: Yeka Adoke, Rella Zoleko-Manego, Serge Ouoba, Alfred B. Tiono, Grace Kaguthi, Juvêncio Eduardo Bonzela, Tran Thanh Duong, Alain Nahum, Marielle Bouyou-Akotet, Bernhards Ogutu, Alphonse Ouedraogo, Fiona Macintyre, Andreas Jessel, Bart Laurijssens, Mohammed H. Cherkaoui-Rbati, Cathy Cantalloube, Anne Claire Marrast, Raphaël Bejuit, David White, Timothy N. C. Wells, Florian Wartha, Didier Leroy, Afizi Kibuuka, Ghyslain Mombo-Ngoma, Daouda Ouattara, Irène Mugenya, Bui Quang Phuc, Francis Bohissou, Denise P. Mawili-Mboumba, Fredrick Olewe, Issiaka Soulama, Halidou Tinto, the FALCI Study Group
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Malaria Journal
Subjects:
Ferroquine
Combination treatment
Pharmacokinetics/pharmacodynamics
Exposure–response
C580Y
Kelch-13 mutation
Online Access:https://doi.org/10.1186/s12936-021-03749-4

Internet

https://doi.org/10.1186/s12936-021-03749-4

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