GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration

GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 replication by limiting viral integration

Abstract GCN2 is a serine/threonine kinase involved in cellular stress response related to amino acid starvation. Previously, we showed that GCN2 interacts with HIV-1 integrase and is activated during HIV-1 infection. Herein, we identified HIV-1 integrase as a previously unknown substrate of GCN2 in...

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Bibliographic Details
Main Authors: A. Jaspart, C. Calmels, O. Cosnefroy, P. Bellecave, P. Pinson, S. Claverol, V. Guyonnet-Dupérat, B. Dartigues, M. S. Benleulmi, E. Mauro, P. A. Gretteau, V. Parissi, M. Métifiot, M. L. Andreola
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02276-0

Internet

https://doi.org/10.1038/s41598-017-02276-0

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