Antiproliferative Properties and G-Quadruplex-Binding of Symmetrical Naphtho[1,2-b:8,7-b’]dithiophene Derivatives

Antiproliferative Properties and G-Quadruplex-Binding of Symmetrical Naphtho[1,2-b:8,7-b’]dithiophene Derivatives

<i>Background</i><i>:</i> G-quadruplex (G4) forming sequences are recurrent in telomeres and promoter regions of several protooncogenes. In normal cells, the transient arrangements of DNA in G-tetrads may regulate replication, transcription, and translation processes. Tumors...

Full description

Bibliographic Details
Main Authors: Antonino Lauria, Gabriele La Monica, Alessio Terenzi, Giuseppe Mannino, Riccardo Bonsignore, Alessia Bono, Anna Maria Almerico, Giampaolo Barone, Carla Gentile, Annamaria Martorana
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
planar heterocyclic scaffold
molecular docking
synthesis
G-Quadruplex
h-Telo
c-MYC
Online Access:https://www.mdpi.com/1420-3049/26/14/4309

Internet

https://www.mdpi.com/1420-3049/26/14/4309

Similar Items