Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders

Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders

Mutations in the mechanotransduction channel component TMC1/2 cause deafness. Here, the authors use a synthetic AAV to replace TMC1 and 2 in the inner ear and show restoration of cochlear and vestibular function, of neuronal reponses in the auditory cortex and of hearing and balance in mice.

Bibliographic Details
Main Authors: Carl A. Nist-Lund, Bifeng Pan, Amy Patterson, Yukako Asai, Tianwen Chen, Wu Zhou, Hong Zhu, Sandra Romero, Jennifer Resnik, Daniel B. Polley, Gwenaelle S. Géléoc, Jeffrey R. Holt
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08264-w

Internet

https://doi.org/10.1038/s41467-018-08264-w

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