Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders
Mutations in the mechanotransduction channel component TMC1/2 cause deafness. Here, the authors use a synthetic AAV to replace TMC1 and 2 in the inner ear and show restoration of cochlear and vestibular function, of neuronal reponses in the auditory cortex and of hearing and balance in mice.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-08264-w |
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doaj-998ee4b6a33b41c587d88c8b399215ea2021-05-11T12:10:16ZengNature Publishing GroupNature Communications2041-17232019-01-0110111410.1038/s41467-018-08264-wImproved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disordersCarl A. Nist-Lund0Bifeng Pan1Amy Patterson2Yukako Asai3Tianwen Chen4Wu Zhou5Hong Zhu6Sandra Romero7Jennifer Resnik8Daniel B. Polley9Gwenaelle S. Géléoc10Jeffrey R. Holt11Department of Otolaryngology and F.M. Kirby Neurobiology Center, Boston Children’s HospitalDepartment of Otolaryngology and F.M. Kirby Neurobiology Center, Boston Children’s HospitalDepartment of Otolaryngology and F.M. Kirby Neurobiology Center, Boston Children’s HospitalDepartment of Otolaryngology and F.M. Kirby Neurobiology Center, Boston Children’s HospitalDepartment of Otolaryngology and Communicative Sciences, University of Mississippi Medical CenterDepartment of Otolaryngology and Communicative Sciences, University of Mississippi Medical CenterDepartment of Otolaryngology and Communicative Sciences, University of Mississippi Medical CenterEaton-Peabody Laboratories, Massachusetts Eye and Ear InfirmaryDepartment of Otolaryngology, Harvard Medical SchoolDepartment of Otolaryngology, Harvard Medical SchoolDepartment of Otolaryngology and F.M. Kirby Neurobiology Center, Boston Children’s HospitalDepartment of Otolaryngology and F.M. Kirby Neurobiology Center, Boston Children’s HospitalMutations in the mechanotransduction channel component TMC1/2 cause deafness. Here, the authors use a synthetic AAV to replace TMC1 and 2 in the inner ear and show restoration of cochlear and vestibular function, of neuronal reponses in the auditory cortex and of hearing and balance in mice.https://doi.org/10.1038/s41467-018-08264-w |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Carl A. Nist-Lund Bifeng Pan Amy Patterson Yukako Asai Tianwen Chen Wu Zhou Hong Zhu Sandra Romero Jennifer Resnik Daniel B. Polley Gwenaelle S. Géléoc Jeffrey R. Holt |
| spellingShingle |
Carl A. Nist-Lund Bifeng Pan Amy Patterson Yukako Asai Tianwen Chen Wu Zhou Hong Zhu Sandra Romero Jennifer Resnik Daniel B. Polley Gwenaelle S. Géléoc Jeffrey R. Holt Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders Nature Communications |
| author_facet |
Carl A. Nist-Lund Bifeng Pan Amy Patterson Yukako Asai Tianwen Chen Wu Zhou Hong Zhu Sandra Romero Jennifer Resnik Daniel B. Polley Gwenaelle S. Géléoc Jeffrey R. Holt |
| author_sort |
Carl A. Nist-Lund |
| title |
Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders |
| title_short |
Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders |
| title_full |
Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders |
| title_fullStr |
Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders |
| title_full_unstemmed |
Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders |
| title_sort |
improved tmc1 gene therapy restores hearing and balance in mice with genetic inner ear disorders |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-01-01 |
| description |
Mutations in the mechanotransduction channel component TMC1/2 cause deafness. Here, the authors use a synthetic AAV to replace TMC1 and 2 in the inner ear and show restoration of cochlear and vestibular function, of neuronal reponses in the auditory cortex and of hearing and balance in mice. |
| url |
https://doi.org/10.1038/s41467-018-08264-w |
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