Pertussis Toxin Exploits Host Cell Signaling Pathways Induced by Meningitis-Causing E. coli K1-RS218 and Enhances Adherence of Monocytic THP-1 Cells to Human Cerebral Endothelial Cells

Pertussis Toxin Exploits Host Cell Signaling Pathways Induced by Meningitis-Causing E. coli K1-RS218 and Enhances Adherence of Monocytic THP-1 Cells to Human Cerebral Endothelial Cells

Pertussis toxin (PTx), the major virulence factor of the whooping cough-causing bacterial pathogen Bordetella pertussis, permeabilizes the blood–brain barrier (BBB) in vitro and in vivo. Breaking barriers might promote translocation of meningitis-causing bacteria across the BBB, thereby facilitating...

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Bibliographic Details
Main Authors: Laura Julia Starost, Sascha Karassek, Yasuteru Sano, Takashi Kanda, Kwang Sik Kim, Ulrich Dobrindt, Christian Rüter, Marcus Alexander Schmidt
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Toxins
Subjects:
pertussis toxin
MAPK p38
neonatal meningitis-causing E. coli K1-RS218
NMEC
NF-κB
blood–brain barrier
Online Access:http://www.mdpi.com/2072-6651/8/10/291

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http://www.mdpi.com/2072-6651/8/10/291

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