Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite

Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite

Phomoxanthone A, a bioactive xanthone dimer isolated from the endophytic fungus <i>Phomopsis </i>sp., is a mitochondrial toxin weakening cellular respiration and electron transport chain activity by a fast breakup of the mitochondrial assembly. Here, a multi-disciplinary strategy has bee...

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Bibliographic Details
Main Authors: Sara Ceccacci, Jana Deitersen, Matteo Mozzicafreddo, Elva Morretta, Peter Proksch, Sebastian Wesselborg, Björn Stork, Maria Chiara Monti
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Biomolecules
Subjects:
proteomics
drug affinity responsive target stability
targeted-limited proteolysis
bioactive xanthone
molecular docking
Online Access:https://www.mdpi.com/2218-273X/10/6/846

Internet

https://www.mdpi.com/2218-273X/10/6/846

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