Evaluating the current state of Mendelian randomization studies: a protocol for a systematic review on methodological and clinical aspects using neurodegenerative disorders as outcome

Evaluating the current state of Mendelian randomization studies: a protocol for a systematic review on methodological and clinical aspects using neurodegenerative disorders as outcome

Abstract Background Mendelian randomization (MR) is fast becoming a popular method to judge causality from routinely conducted observational studies. However, stringent underlying statistical assumptions, missing biological information, and high sample size requirement might make it prone to misuse....

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Bibliographic Details
Main Authors: Sandeep Grover, Fabiola Del Greco M., Inke R. König
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Systematic Reviews
Subjects:
Mendelian randomization
Instrumental variable
Observational epidemiology
Genome-wide association study
Summary data
Pleiotropy
Online Access:http://link.springer.com/article/10.1186/s13643-018-0809-3

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http://link.springer.com/article/10.1186/s13643-018-0809-3

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