A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion

A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion

Summary: Guided by a multi-level “deconstruction” of omental metastases, we developed a tetra (four cell)-culture model of primary human mesothelial cells, fibroblasts, adipocytes, and high-grade serous ovarian cancer (HGSOC) cell lines. This multi-cellular model replicated key elements of human met...

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Bibliographic Details
Main Authors: Beatrice Malacrida, Sam Nichols, Eleni Maniati, Roanne Jones, Robin Delanie-Smith, Reza Roozitalab, Eleanor J. Tyler, Morgan Thomas, Gina Boot, Jonas Mackerodt, Michelle Lockley, Martin M. Knight, Frances R. Balkwill, Oliver M.T. Pearce
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:iScience
Subjects:
biological sciences
cancer systems biology
cell biology
methodology in biological sciences
molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221006441

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http://www.sciencedirect.com/science/article/pii/S2589004221006441

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