Targeting of Topoisomerase I for Prognoses and Therapeutics of Camptothecin-Resistant Ovarian Cancer.

Targeting of Topoisomerase I for Prognoses and Therapeutics of Camptothecin-Resistant Ovarian Cancer.

DNA topoisomerase I (TOP1) levels of several human neoplasms are higher than those of normal tissues. TOP1 inhibitors are widely used in treating conventional therapy-resistant ovarian cancers. However, patients may develop resistance to TOP1 inhibitors, hampering chemotherapy success. In this study...

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Bibliographic Details
Main Authors: Yu-Chieh Lee, Chii-Hong Lee, Hsiang-Ping Tsai, Herng-Wei An, Chi-Ming Lee, Jen-Chine Wu, Chien-Shu Chen, Shih-Hao Huang, Jaulang Hwang, Kur-Ta Cheng, Phui-Ly Leiw, Chi-Long Chen, Chun-Mao Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4514822?pdf=render

Internet

http://europepmc.org/articles/PMC4514822?pdf=render

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