Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice.

Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice.

Chronic obstructive pulmonary disease (COPD) is a widespread disease, with no curative therapies available. Recent findings suggest a key role of NO and sGC-cGMP signaling for the pathogenesis of the disease. Previous data suggest a downregulation/inactivation of the cGMP producing soluble guanylate...

Full description

Bibliographic Details
Main Authors: Michael Seimetz, Nirmal Parajuli, Alexandra Pichl, Mariola Bednorz, Hossein Ardeschir Ghofrani, Ralph Theo Schermuly, Werner Seeger, Friedrich Grimminger, Norbert Weissmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4461257?pdf=render

Internet

http://europepmc.org/articles/PMC4461257?pdf=render

Similar Items