Ameliorative Effects of PACAP against Cartilage Degeneration. Morphological, Immunohistochemical and Biochemical Evidence from in Vivo and in Vitro Models of Rat Osteoarthritis

Ameliorative Effects of PACAP against Cartilage Degeneration. Morphological, Immunohistochemical and Biochemical Evidence from in Vivo and in Vitro Models of Rat Osteoarthritis

Osteoarthritis (OA); the most common form of degenerative joint disease, is associated with variations in pro-inflammatory growth factor levels, inflammation and hypocellularity resulting from chondrocyte apoptosis. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide endowe...

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Bibliographic Details
Main Authors: Salvatore Giunta, Alessandro Castorina, Rubina Marzagalli, Marta Anna Szychlinska, Karin Pichler, Ali Mobasheri, Giuseppe Musumeci
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:International Journal of Molecular Sciences
Subjects:
pituitary adenylate cyclase-activating polypeptide (PACAP)
Osteoarthritis
anterior cruciate ligament transection (ACLT)
immunohistochemistry
Bcl-2
BAX
caspase-3
Online Access:http://www.mdpi.com/1422-0067/16/3/5922

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http://www.mdpi.com/1422-0067/16/3/5922

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