Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia

Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia

Abstract Background Acute lymphoblastic leukemia (ALL) is a clonal malignant disorder characterized by an uncontrolled proliferation of immature B or T lymphocytes. Extensive studies have suggested an involvement of angiogenesis signaling in ALL progression and resistance to treatment. Thus, targeti...

Full description

Bibliographic Details
Main Authors: Manman Deng, Jie Zha, Zhiwu Jiang, Xian Jia, Yuanfei Shi, Peng Li, Xiao Lei Chen, Zhihong Fang, Zhiqiang Du, Bing Xu
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Translational Medicine
Subjects:
Apatinib
Acute lymphoblastic leukemia
VEGFR2
Leukemia therapy
Anti-angiogenic agent
Online Access:http://link.springer.com/article/10.1186/s12967-018-1421-y

Internet

http://link.springer.com/article/10.1186/s12967-018-1421-y

Similar Items