Exploring DNA topoisomerase I ligand space in search of novel anticancer agents.

Exploring DNA topoisomerase I ligand space in search of novel anticancer agents.

DNA topoisomerase I (Top1) is over-expressed in tumour cells and is an important target in cancer chemotherapy. It relaxes DNA torsional strain generated during DNA processing by introducing transient single-strand breaks and allowing the broken strand to rotate around the intermediate Top1-DNA cova...

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Bibliographic Details
Main Authors: Malgorzata N Drwal, Keli Agama, Laurence P G Wakelin, Yves Pommier, Renate Griffith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3178613?pdf=render

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http://europepmc.org/articles/PMC3178613?pdf=render

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