Regulation of the Transferrin Receptor Recycling in Hepatitis C Virus-Replicating Cells

Regulation of the Transferrin Receptor Recycling in Hepatitis C Virus-Replicating Cells

After binding of its ligand transferrin, the transferrin receptor (TfR) is internalized via early endosomes. Ligand and receptor can be recycled. α-Taxilin was identified as an essential factor for TfR recycling. Apart from its role for iron uptake, TfR is a coreceptor for hepatitis C virus (HCV) in...

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Bibliographic Details
Main Authors: Vanessa Haberger, Fabian Elgner, Jessica Roos, Daniela Bender, Eberhard Hildt
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
α-taxilin
hepatitis C virus
transferrin receptor
iron metabolism
HCV superinfection
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00044/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00044/full

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