Heparan Sulfate Proteoglycans May Promote or Inhibit Cancer Progression by Interacting with Integrins and Affecting Cell Migration

The metastatic disease is one of the main consequences of tumor progression, being responsible for most cancer-related deaths worldwide. This review intends to present and discuss data on the relationship between integrins and heparan sulfate proteoglycans in health and cancer progression. Integrins...

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Bibliographic Details
Main Authors: Mariana A. Soares, Felipe C. O. B. Teixeira, Miguel Fontes, Ana Lúcia Arêas, Marcelo G. Leal, Mauro S. G. Pavão, Mariana P. Stelling
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/453801