Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicity

Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicity

The post-mortem brains of individuals with Parkinson's disease (PD) and other synucleinopathy disorders are characterized by the presence of aggregated forms of the presynaptic protein α-synuclein (aSyn). Understanding the molecular mechanism of aSyn aggregation is essential for the development...

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Bibliographic Details
Main Authors: Daniel Ysselstein, Mehul Joshi, Vartika Mishra, Amy M. Griggs, Josephat M. Asiago, George P. McCabe, Lia A. Stanciu, Carol Beth Post, Jean-Christophe Rochet
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Neurobiology of Disease
Subjects:
Aggregation
α-Helix
α-Synuclein
Familial mutation
Membrane
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115001540

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http://www.sciencedirect.com/science/article/pii/S0969996115001540

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