Dual Targeting of the p38 MAPK-HO-1 Axis and cIAP1/XIAP by Demethoxycurcumin Triggers Caspase-Mediated Apoptotic Cell Death in Oral Squamous Cell Carcinoma Cells

Dual Targeting of the p38 MAPK-HO-1 Axis and cIAP1/XIAP by Demethoxycurcumin Triggers Caspase-Mediated Apoptotic Cell Death in Oral Squamous Cell Carcinoma Cells

Demethoxycurcumin (DMC) is a curcumin analogue with better stability and higher aqueous solubility than curcumin after oral ingestion and has the potential to treat diverse cancers, including oral squamous cell carcinoma (OSCC). The aim of this study was to investigate the anticancer effects and und...

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Bibliographic Details
Main Authors: Ming-Hsien Chien, Wei-En Yang, Yi-Chieh Yang, Chia-Chi Ku, Wei-Jiunn Lee, Meng-Ying Tsai, Chiao-Wen Lin, Shun-Fa Yang
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
demethoxycurcumin
apoptosis
inhibitor of apoptosis proteins
heme oxygenase-1
oral squamous cell carcinoma
Online Access:https://www.mdpi.com/2072-6694/12/3/703

Internet

https://www.mdpi.com/2072-6694/12/3/703

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