Mode of Action Analyses of Neferine, a Bisbenzylisoquinoline Alkaloid of Lotus (Nelumbo nucifera) against Multidrug-Resistant Tumor Cells

Mode of Action Analyses of Neferine, a Bisbenzylisoquinoline Alkaloid of Lotus (Nelumbo nucifera) against Multidrug-Resistant Tumor Cells

Neferine, a bisbenzylisoquinoline alkaloid isolated from the green seed embryos of Lotus (Nelumbo nucifera Gaertn), has been previously shown to have various anti-cancer effects. In the present study, we evaluated the effect of neferine in terms of P-glycoprotein (P-gp) inhibition via in vitro cytot...

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Bibliographic Details
Main Authors: Onat Kadioglu, Betty Y. K. Law, Simon W. F. Mok, Su-Wei Xu, Thomas Efferth, Vincent K. W. Wong
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Pharmacology
Subjects:
cancer
chemotherapy
drug resistance
natural products
neferine
P-glycoprotein
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00238/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00238/full

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